Simultaneous determination of 10 spiked chemical drugs in antihypertensive herb preparations and health foods by microemulsion liquid chromatography

doi:10.3724/SP.J.1123.2016.09019

Abstract

Abstract:

A method was developed for simultaneous determination of 10 spiked chemical drugs in antihypertensive herb preparations and health foods by microemulsion liquid chromatography (MELC). The nature and mass fraction of microemulsion components (surfactant, co-surfactant, and oil phase), the pH of microemulsion, and the type of the stationary-phase were investigated. Central composite design-response surface methodology was used. The optimized conditions for the separation of the 10 spiked chemical drugs were as follows:an Agela Promosil C18(2) column (250 mm×4.6 mm, 5 μm) was used at 30℃, and the microemulsion mobile phase (pH 3.0) consisted of 5.6% (mass fraction) polyoxyethylene lauryl ether (Brij35), 0.17% (mass fraction) sodium dodecylsulfate (SDS), 5.1% (mass fraction) n-butanol, 0.46% (mass fraction) cyclohexane and water (pH 3.0). The method is efficient, sensitive and environment friendly.

Key words: antihypertensive, chemical drugs, health foods, herb preparations, microemulsion liquid chromatography (MELC)

CLC Number:

O658

LI Liangxing, LAI Caiyun, ZHENG Aini, WU Hongxing, SU Caoyin, GAO Chongkai, LI Ning. Simultaneous determination of 10 spiked chemical drugs in antihypertensive herb preparations and health foods by microemulsion liquid chromatography[J]. Chinese Journal of Chromatography, 2017, 35(2): 203-210.

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