Chinese Journal of Chromatography ›› 2021, Vol. 39 ›› Issue (7): 695-701.DOI: 10.3724/SP.J.1123.2020.09020
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HUANG Yongpeng, TANG Hui, SONG Yunyang, CHEN Bo*(), ZHONG Hui*()
Received:
2020-09-30
Online:
2021-07-08
Published:
2021-06-02
Contact:
CHEN Bo,ZHONG Hui
CLC Number:
HUANG Yongpeng, TANG Hui, SONG Yunyang, CHEN Bo, ZHONG Hui. Simultaneous determination of three quaternary ammonium muscle relaxants in blood by high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2021, 39(7): 695-701.
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URL: https://www.chrom-china.com/EN/10.3724/SP.J.1123.2020.09020
Compound | Precursor ion | Mass transition (m/z) | Fragmentor/ V | Collision energy/ eV |
---|---|---|---|---|
Vecuronium | [M-Br-+H]2+ | 279.2/100.1 | 131 | 24 |
bromide | 279.2/249.2* | 8 | ||
Rocuronium | [M-Br-+H]2+ | 265.2/235.1 | 122 | 12 |
bromide | 265.2/244.2* | 9 | ||
Pancuronium | [M-2Br-]2+ | 286.6/100.1* | 123 | 21 |
bromide | 286.6/256.2 | 10 |
Table 1 MS parameters for three muscle relaxants
Compound | Precursor ion | Mass transition (m/z) | Fragmentor/ V | Collision energy/ eV |
---|---|---|---|---|
Vecuronium | [M-Br-+H]2+ | 279.2/100.1 | 131 | 24 |
bromide | 279.2/249.2* | 8 | ||
Rocuronium | [M-Br-+H]2+ | 265.2/235.1 | 122 | 12 |
bromide | 265.2/244.2* | 9 | ||
Pancuronium | [M-2Br-]2+ | 286.6/100.1* | 123 | 21 |
bromide | 286.6/256.2 | 10 |
Compound | Linear range/ (ng/mL) | Linear equation | R2 | LOD/ (ng/mL) | LOQ/ (ng/mL) | Recovery/% | RSD (n=6)/% |
---|---|---|---|---|---|---|---|
Vecuronium bromide | 0.5-1000 | Y=79.68X+945.47 | 0.9967 | 0.2 | 0.5 | 92.8-108.3 | 3.2-5.6 |
Rocuronium bromide | 2.0-1000 | Y=107.36X-3040.50 | 0.9972 | 0.8 | 2.0 | 94.3-106.2 | 4.2-5.4 |
Pancuronium bromide | 1.7-1000 | Y=88.68X-1881.70 | 0.9963 | 0.7 | 1.7 | 97.9-110.6 | 5.5-9.4 |
Table 2 Linear ranges, linear equations, correlation coefficients (R2), LODs, LOQs, recoveries and RSDs of the three muscle relaxants
Compound | Linear range/ (ng/mL) | Linear equation | R2 | LOD/ (ng/mL) | LOQ/ (ng/mL) | Recovery/% | RSD (n=6)/% |
---|---|---|---|---|---|---|---|
Vecuronium bromide | 0.5-1000 | Y=79.68X+945.47 | 0.9967 | 0.2 | 0.5 | 92.8-108.3 | 3.2-5.6 |
Rocuronium bromide | 2.0-1000 | Y=107.36X-3040.50 | 0.9972 | 0.8 | 2.0 | 94.3-106.2 | 4.2-5.4 |
Pancuronium bromide | 1.7-1000 | Y=88.68X-1881.70 | 0.9963 | 0.7 | 1.7 | 97.9-110.6 | 5.5-9.4 |
No. | Vecuronium bromide/(ng/mL) | Rocuronium bromide/(ng/mL) | Pancuronium bromide/(ng/mL) |
---|---|---|---|
1 | ND | ND | 428 |
2 | 364 | ND | ND |
3 | ND | 450 | ND |
4 | 231 | 173 | 287 |
Table 3 Determination results of four rabbit blood samples (n=3)
No. | Vecuronium bromide/(ng/mL) | Rocuronium bromide/(ng/mL) | Pancuronium bromide/(ng/mL) |
---|---|---|---|
1 | ND | ND | 428 |
2 | 364 | ND | ND |
3 | ND | 450 | ND |
4 | 231 | 173 | 287 |
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