Chinese Journal of Chromatography ›› 2023, Vol. 41 ›› Issue (1): 47-57.DOI: 10.3724/SP.J.1123.2022.04017
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QU Tao2, CHEN Yang1, YANG Changjun2, LIU Qisong2, CHEN Hui2, HE Zhiyong1, WANG Zhaojun1, CHEN Jie1, ZENG Maomao1,*()
Received:
2022-04-21
Online:
2023-01-08
Published:
2023-01-12
Contact:
ZENG Maomao
Supported by:
CLC Number:
QU Tao, CHEN Yang, YANG Changjun, LIU Qisong, CHEN Hui, HE Zhiyong, WANG Zhaojun, CHEN Jie, ZENG Maomao. Pseudotargeted metabolomics analysis of pine pollen intervention in the liver of premature ovarian failure rats[J]. Chinese Journal of Chromatography, 2023, 41(1): 47-57.
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URL: https://www.chrom-china.com/EN/10.3724/SP.J.1123.2022.04017
Fig. 3 Orthogonal partial least squares-discrimination analysis (OPLS-DA) score plots, S-plots, and volcano maps for the various groups in the positive model Control: control group; Cyclophosphamide: model group; Estrogen: estrogen group; Pine pollen-L: low-dose pine pollen group; Pine pollen-M: medium-dose pine pollen group; Pine pollen-H: high-dose pine pollen group.
No. | Metabolite | MG vs CG | MG vs EG | MG vs PG. L | MG vs PG. M | MG vs PG. H |
---|---|---|---|---|---|---|
1 | 2-hydroxyquinoline | ↑ | ↑ | ↑ | ↑ | ↑ |
2 | 3-indolepropionic acid | ↑ | ↑ | ↑ | ↑ | ↑ |
3 | 4-guanidinobutanoic acid | ↑ | ↑ | ↑ | ↑ | ↑ |
4 | 4-hydroxyquinoline | ↑ | ↑ | ↑ | ||
5 | decanoylcarnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
6 | decenoylcarnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
7 | dodecenoylcarnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
8 | propionylcarnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
9 | butyrylcarnitine | ↓ | ↓ | |||
10 | 2-octenoyl-L-carnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
11 | allantoin | ↑ | ↑ | |||
12 | aminoadipic acid | ↓ | ↓ | ↓ | ↓ | |
13 | 3-amino-2-oxazolidinone | ↑ | ||||
14 | cinnamic acid | ↑ | ||||
15 | cytidine monophosphate | ↓ | ↓ | ↓ | ↓ | ↓ |
16 | cytosine | ↑ | ↑ | ↑ | ↑ | ↑ |
17 | D-(+)-octopine | ↑ | ↑ | ↑ | ↑ | |
18 | deoxyadenosine monophosphate | ↓ | ↓ | ↓ | ↓ | ↓ |
19 | dimethylguanosine | ↑ | ||||
20 | estriol | ↓ | ||||
21 | gamma-aminobutyric acid | ↑ | ↑ | ↑ | ||
22 | glycerophosphocholine | ↑ | ↑ | ↑ | ↑ | ↑ |
23 | glycodeoxycholic acid | ↑ | ↑ | ↑ | ||
24 | glycohyocholic acid | ↑ | ↑ | ↑ | ↑ | |
25 | glycyl-glycine | ↑ | ↑ | ↑ | ↑ | ↑ |
26 | homo-L-arginine | ↑ | ↑ | ↑ | ||
27 | imidazoleacetic acid | ↑ | ↑ | ↑ | ↑ | ↑ |
28 | indole | ↑ | ||||
29 | indole-3-propionic acid | ↑ | ↑ | |||
30 | indolelactic acid | ↑ | ↑ | ↑ | ||
31 | indoline | ↑ | ||||
32 | L-cysteine | ↑ | ↑ | |||
33 | lipoamide | ↑ | ↑ | ↑ | ||
34 | lysophosphatidylcholine 3∶1 | ↑ | ↑ | ↑ | ↑ | |
35 | nicotyrine | ↑ | ↑ | ↑ | ||
36 | O-butanoylcarnitine | ↓ | ||||
37 | ornithine | ↑ | ||||
38 | Phe-Phe | ↑ | ↑ | |||
39 | propionyl-carnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
40 | purine | ↑ | ↑ | |||
41 | pyridoxal 5-phosphate | ↓ | ↓ | ↓ | ↓ | ↓ |
42 | ribothymidine | ↑ | ↑ | |||
43 | trigonelline | ↑ | ↑ | ↑ | ↑ | ↑ |
44 | trimethylamine N-oxide | ↑ | ↑ | ↑ | ↑ | |
45 | uric acid | ↓ | ↓ | ↓ | ↓ | |
46 | uridine 5-monophosphate | ↑ | ↑ | ↑ | ↑ | ↑ |
47 | 2-aminooctanoic acid | ↓ | ||||
48 | adenosine monophosphate | ↓ | ↓ | ↓ | ||
49 | adenosine monophosphate | ↓ | ↓ | ↓ | ||
50 | cholic acid | ↓ | ↓ | |||
51 | glycocholic | ↑ | ↑ | |||
52 | glycerophosphocholine | ↑ | ↑ | ↑ | ||
53 | inosinic acid | ↓ | ↓ | ↓ | ↓ | |
54 | linolenic acid | ↑ | ||||
55 | Pro-Leu | ↓ | ↓ | |||
56 | remerine | ↑ | ↑ | |||
No. | Metabolite | MG vs CG | MG vs EG | MG vs PG. L | MG vs PG. M | MG vs PG. H |
57 | uridine | ↑ | ↑ | |||
58 | xanthosine | ↑ | ↑ | |||
59 | 2,3-diaminopropionic acid | ↑ | ||||
60 | decadienylcarnitine | ↑ | ||||
61 | acetyl-carnitine | ↑ | ||||
62 | L-acetylcarnitine | ↑ | ||||
63 | mannose 6-phosphate 2 | ↑ | ||||
64 | Phe-Trp | ↑ | ||||
65 | 2-methylbutyroyl carnitine | ↓ | ||||
66 | 3-pyridylacetic acid | ↓ | ||||
67 | isovalerylcarnitine | ↓ | ||||
68 | (S)-2-acetamidohexanoic acid | ↓ | ||||
69 | m-aminobenzoic acid | ↓ | ||||
70 | methylbutyroyl-carnitine | ↓ | ||||
71 | 15,16-dihydroxy-9Z,12Z-octadecadienoic acid | ↑ | ↑ | ↑ | ↑ | ↑ |
72 | 2-hydroxy-2-methylbutyric acid | ↓ | ↓ | ↓ | ↓ | ↓ |
73 | 2-hydroxy-3-oxopropanoate | ↓ | ↓ | |||
74 | 3-phosphoglycerate | ↓ | ↓ | ↓ | ↓ | ↓ |
75 | 3-α,20-α-dihydroxy-5-β-pregnane 3-glucuronide | ↓ | ↑ | ↓ | ||
76 | 4-hydroxybutanoic acid | ↓ | ↓ | |||
77 | albiflorin | ↓ | ↓ | ↓ | ↓ | |
78 | dehydroepiandrosterone sulfate/dihydrotestosterone | ↓ | ↑ | ↓ | ||
79 | benzophenone-2 | ↑ | ↑ | ↑ | ↑ | |
80 | biliverdin | ↓ | ↓ | |||
81 | citrulline | ↓ | ↓ | ↓ | ||
82 | cortolone-3-glucuronide | ↓ | ↓ | |||
83 | fatty acid 16∶1 | ↑ | ↑ | ↑ | ↑ | |
84 | fatty acid 17∶1 | ↑ | ↑ | |||
85 | glycocholic acid | ↑ | ↑ | ↑ | ↑ | |
86 | glycoursodeoxycholic acid | ↑ | ↑ | ↑ | ||
87 | haematommic acid | ↓ | ↓ | |||
88 | hippuric acid | ↑ | ↑ | ↑ | ↑ | ↑ |
89 | indolelactate | ↑ | ↑ | |||
90 | indoxyl sulfate | ↑ | ↑ | |||
91 | inosine | ↓ | ↓ | ↓ | ↓ | |
92 | L-(-)-3-phenyllactic acid | ↑ | ↑ | |||
93 | L-tryptophan | ↑ | ↑ | |||
94 | paracetamol sulfate | ↑ | ↑ | ↑ | ||
95 | phosphoenolpyruvate (PEP 1) | ↓ | ↓ | ↓ | ↓ | ↓ |
96 | taurodeoxycholic acid | ↑ | ↑ | ↑ | ||
97 | tetrahydroalstonine | ↓ | ↓ | |||
98 | trans-cinnamic acid | ↑ | ↑ | |||
99 | urate | ↓ | ↓ | ↓ | ||
100 | γ-glutamylphenylalanine | ↑ | ||||
101 | 2-methylglutaric acid | ↑ | ||||
102 | 2-naphthylamine | ↓ | ↓ | ↓ | ↓ | |
103 | 9,10-dihydroxy-12-octadecenoic acid | ↓ | ↓ | |||
104 | cholic acid | ↓ | ↓ | |||
105 | deoxycholic acid | ↓ | ↓ | |||
106 | DL-p-hydroxyphenyl lactic acid | ↓ | ↓ | |||
107 | D-ribose 5-phophate | ↑ | ↑ | |||
108 | fructose 6-phosphate | ↑ | ↑ | |||
109 | heptadecanoic acid | ↑ | ↑ | ↑ | ||
110 | hexadecanedioic acid | ↓ | ↓ | |||
111 | N-acetyl-O-acetylneuraminate | ↓ | ↓ | |||
112 | O-2545 (hydrochloride) | ↓ | ↓ | |||
No. | Metabolite | MG vs CG | MG vs EG | MG vs PG. L | MG vs PG. M | MG vs PG. H |
113 | p-cresol sulfate | ↓ | ↓ | |||
114 | phosphoric acid | ↓ | ↓ | |||
115 | (S)-3-sulfolactate | ↑ | ||||
116 | 7β,12α-dihydroxy-5α-cholan-24-oic acid | ↓ | ||||
117 | acetylenedicarboxylate | ↓ | ↓ | |||
118 | deoxycholic acid 3-glucuronide | ↓ | ||||
119 | DL-glyceraldehyde 3-phosphate | ↑ | ||||
120 | fatty acid 20∶2 | ↑ | ||||
121 | 2-aminoethylphosphonic acid | ↓ | ||||
122 | fatty acid esters of hydroxy fatty acids 38∶3 | ↓ | ||||
123 | 1,6-bisphosphatase 1 | ↓ | ||||
124 | erucic acid | ↑ |
Table 1 Variations in the differential metabolites in the various rat groups
No. | Metabolite | MG vs CG | MG vs EG | MG vs PG. L | MG vs PG. M | MG vs PG. H |
---|---|---|---|---|---|---|
1 | 2-hydroxyquinoline | ↑ | ↑ | ↑ | ↑ | ↑ |
2 | 3-indolepropionic acid | ↑ | ↑ | ↑ | ↑ | ↑ |
3 | 4-guanidinobutanoic acid | ↑ | ↑ | ↑ | ↑ | ↑ |
4 | 4-hydroxyquinoline | ↑ | ↑ | ↑ | ||
5 | decanoylcarnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
6 | decenoylcarnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
7 | dodecenoylcarnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
8 | propionylcarnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
9 | butyrylcarnitine | ↓ | ↓ | |||
10 | 2-octenoyl-L-carnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
11 | allantoin | ↑ | ↑ | |||
12 | aminoadipic acid | ↓ | ↓ | ↓ | ↓ | |
13 | 3-amino-2-oxazolidinone | ↑ | ||||
14 | cinnamic acid | ↑ | ||||
15 | cytidine monophosphate | ↓ | ↓ | ↓ | ↓ | ↓ |
16 | cytosine | ↑ | ↑ | ↑ | ↑ | ↑ |
17 | D-(+)-octopine | ↑ | ↑ | ↑ | ↑ | |
18 | deoxyadenosine monophosphate | ↓ | ↓ | ↓ | ↓ | ↓ |
19 | dimethylguanosine | ↑ | ||||
20 | estriol | ↓ | ||||
21 | gamma-aminobutyric acid | ↑ | ↑ | ↑ | ||
22 | glycerophosphocholine | ↑ | ↑ | ↑ | ↑ | ↑ |
23 | glycodeoxycholic acid | ↑ | ↑ | ↑ | ||
24 | glycohyocholic acid | ↑ | ↑ | ↑ | ↑ | |
25 | glycyl-glycine | ↑ | ↑ | ↑ | ↑ | ↑ |
26 | homo-L-arginine | ↑ | ↑ | ↑ | ||
27 | imidazoleacetic acid | ↑ | ↑ | ↑ | ↑ | ↑ |
28 | indole | ↑ | ||||
29 | indole-3-propionic acid | ↑ | ↑ | |||
30 | indolelactic acid | ↑ | ↑ | ↑ | ||
31 | indoline | ↑ | ||||
32 | L-cysteine | ↑ | ↑ | |||
33 | lipoamide | ↑ | ↑ | ↑ | ||
34 | lysophosphatidylcholine 3∶1 | ↑ | ↑ | ↑ | ↑ | |
35 | nicotyrine | ↑ | ↑ | ↑ | ||
36 | O-butanoylcarnitine | ↓ | ||||
37 | ornithine | ↑ | ||||
38 | Phe-Phe | ↑ | ↑ | |||
39 | propionyl-carnitine | ↓ | ↓ | ↓ | ↓ | ↓ |
40 | purine | ↑ | ↑ | |||
41 | pyridoxal 5-phosphate | ↓ | ↓ | ↓ | ↓ | ↓ |
42 | ribothymidine | ↑ | ↑ | |||
43 | trigonelline | ↑ | ↑ | ↑ | ↑ | ↑ |
44 | trimethylamine N-oxide | ↑ | ↑ | ↑ | ↑ | |
45 | uric acid | ↓ | ↓ | ↓ | ↓ | |
46 | uridine 5-monophosphate | ↑ | ↑ | ↑ | ↑ | ↑ |
47 | 2-aminooctanoic acid | ↓ | ||||
48 | adenosine monophosphate | ↓ | ↓ | ↓ | ||
49 | adenosine monophosphate | ↓ | ↓ | ↓ | ||
50 | cholic acid | ↓ | ↓ | |||
51 | glycocholic | ↑ | ↑ | |||
52 | glycerophosphocholine | ↑ | ↑ | ↑ | ||
53 | inosinic acid | ↓ | ↓ | ↓ | ↓ | |
54 | linolenic acid | ↑ | ||||
55 | Pro-Leu | ↓ | ↓ | |||
56 | remerine | ↑ | ↑ | |||
No. | Metabolite | MG vs CG | MG vs EG | MG vs PG. L | MG vs PG. M | MG vs PG. H |
57 | uridine | ↑ | ↑ | |||
58 | xanthosine | ↑ | ↑ | |||
59 | 2,3-diaminopropionic acid | ↑ | ||||
60 | decadienylcarnitine | ↑ | ||||
61 | acetyl-carnitine | ↑ | ||||
62 | L-acetylcarnitine | ↑ | ||||
63 | mannose 6-phosphate 2 | ↑ | ||||
64 | Phe-Trp | ↑ | ||||
65 | 2-methylbutyroyl carnitine | ↓ | ||||
66 | 3-pyridylacetic acid | ↓ | ||||
67 | isovalerylcarnitine | ↓ | ||||
68 | (S)-2-acetamidohexanoic acid | ↓ | ||||
69 | m-aminobenzoic acid | ↓ | ||||
70 | methylbutyroyl-carnitine | ↓ | ||||
71 | 15,16-dihydroxy-9Z,12Z-octadecadienoic acid | ↑ | ↑ | ↑ | ↑ | ↑ |
72 | 2-hydroxy-2-methylbutyric acid | ↓ | ↓ | ↓ | ↓ | ↓ |
73 | 2-hydroxy-3-oxopropanoate | ↓ | ↓ | |||
74 | 3-phosphoglycerate | ↓ | ↓ | ↓ | ↓ | ↓ |
75 | 3-α,20-α-dihydroxy-5-β-pregnane 3-glucuronide | ↓ | ↑ | ↓ | ||
76 | 4-hydroxybutanoic acid | ↓ | ↓ | |||
77 | albiflorin | ↓ | ↓ | ↓ | ↓ | |
78 | dehydroepiandrosterone sulfate/dihydrotestosterone | ↓ | ↑ | ↓ | ||
79 | benzophenone-2 | ↑ | ↑ | ↑ | ↑ | |
80 | biliverdin | ↓ | ↓ | |||
81 | citrulline | ↓ | ↓ | ↓ | ||
82 | cortolone-3-glucuronide | ↓ | ↓ | |||
83 | fatty acid 16∶1 | ↑ | ↑ | ↑ | ↑ | |
84 | fatty acid 17∶1 | ↑ | ↑ | |||
85 | glycocholic acid | ↑ | ↑ | ↑ | ↑ | |
86 | glycoursodeoxycholic acid | ↑ | ↑ | ↑ | ||
87 | haematommic acid | ↓ | ↓ | |||
88 | hippuric acid | ↑ | ↑ | ↑ | ↑ | ↑ |
89 | indolelactate | ↑ | ↑ | |||
90 | indoxyl sulfate | ↑ | ↑ | |||
91 | inosine | ↓ | ↓ | ↓ | ↓ | |
92 | L-(-)-3-phenyllactic acid | ↑ | ↑ | |||
93 | L-tryptophan | ↑ | ↑ | |||
94 | paracetamol sulfate | ↑ | ↑ | ↑ | ||
95 | phosphoenolpyruvate (PEP 1) | ↓ | ↓ | ↓ | ↓ | ↓ |
96 | taurodeoxycholic acid | ↑ | ↑ | ↑ | ||
97 | tetrahydroalstonine | ↓ | ↓ | |||
98 | trans-cinnamic acid | ↑ | ↑ | |||
99 | urate | ↓ | ↓ | ↓ | ||
100 | γ-glutamylphenylalanine | ↑ | ||||
101 | 2-methylglutaric acid | ↑ | ||||
102 | 2-naphthylamine | ↓ | ↓ | ↓ | ↓ | |
103 | 9,10-dihydroxy-12-octadecenoic acid | ↓ | ↓ | |||
104 | cholic acid | ↓ | ↓ | |||
105 | deoxycholic acid | ↓ | ↓ | |||
106 | DL-p-hydroxyphenyl lactic acid | ↓ | ↓ | |||
107 | D-ribose 5-phophate | ↑ | ↑ | |||
108 | fructose 6-phosphate | ↑ | ↑ | |||
109 | heptadecanoic acid | ↑ | ↑ | ↑ | ||
110 | hexadecanedioic acid | ↓ | ↓ | |||
111 | N-acetyl-O-acetylneuraminate | ↓ | ↓ | |||
112 | O-2545 (hydrochloride) | ↓ | ↓ | |||
No. | Metabolite | MG vs CG | MG vs EG | MG vs PG. L | MG vs PG. M | MG vs PG. H |
113 | p-cresol sulfate | ↓ | ↓ | |||
114 | phosphoric acid | ↓ | ↓ | |||
115 | (S)-3-sulfolactate | ↑ | ||||
116 | 7β,12α-dihydroxy-5α-cholan-24-oic acid | ↓ | ||||
117 | acetylenedicarboxylate | ↓ | ↓ | |||
118 | deoxycholic acid 3-glucuronide | ↓ | ||||
119 | DL-glyceraldehyde 3-phosphate | ↑ | ||||
120 | fatty acid 20∶2 | ↑ | ||||
121 | 2-aminoethylphosphonic acid | ↓ | ||||
122 | fatty acid esters of hydroxy fatty acids 38∶3 | ↓ | ||||
123 | 1,6-bisphosphatase 1 | ↓ | ||||
124 | erucic acid | ↑ |
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