Simultaneous determination of 6 forbidden colorants in cosmetics by high performance liquid chromatography-tandem mass spectrometry

doi:10.3724/SP.J.1123.2011.11049

Abstract

Abstract: A method of high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) has been established for the simultaneous determination of six forbidden colorants including Sudan IV, Acid Violet 49, Sudan Blue 2, Solvent Red 49, Basic Violet 1 and Pigment Orange 5 in cream and powdery matrix cosmetics. The samples were extracted with ethanol-acetonitrile (3:2, v/v) solution by ultrasonic technique for 20 min, then centrifuged for purification and enriched by nitrogen blowing sequentially. The analytes were isolated on a Luna C18 column (150 mm×2.1 mm, 5 μm) by gradient elution with methanol and 10 mmol/L ammonium acetate as the mobile phases, and detected by MS/MS in the multiple reaction monitoring (MRM) mode. The qualitative analysis was based on the retention time and the relative abundance ratio of the characteristic ions, and the quantitative analysis on calibration curve method. The results showed that the limits of quantification (LOQ, S/N=10) of the six colorants ranged from 0.1 to 10 μg/kg and the average recoveries were from 86.67% to 98.22% with the relative standard deviations (RSDs) from 4.01% to 7.01%. The method is simple and rapid with high sensitivity and good reproducibility, and suitable for the determination of the six forbidden colorants in cosmetics.

Key words: cosmetics, forbidden colorant, high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)

CLC Number:

O658

LIN Weixuan1*, SUN Xingquan1, ZHAO Xuerong1, XU Wei1, GUO Guiyuan2. Simultaneous determination of 6 forbidden colorants in cosmetics by high performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2012, 30(05): 527-532.

References

Metrics

Viewed

Full text

103

HTTP500 内部服务器出错

http500错误

http 500内部服务器错误，请与管理员联系。

请尝试以下操作：

·打开主页，然后查找指向您感兴趣信息的链接。
·单击后退链接，尝试其他链接。

错误：java.util.ConcurrentModificationException
错误码：500
异常：null
exception:java.util.ConcurrentModificationException
cause:null
message:null
localizedMessage:null
stackTrace:java.util.ConcurrentModificationException at java.util.HashMap$HashIterator.nextNode(HashMap.java:1442) at java.util.HashMap$KeyIterator.next(HashMap.java:1466) at com.lyt.util.filter.CountDayBrowseFilter.docurrent(CountDayBrowseFilter.java:99) at com.lyt.util.filter.CountDayBrowseFilter.doFilter(CountDayBrowseFilter.java:43) at com.lyt.util.HttpFilter.doFilter(HttpFilter.java:46) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166) at org.tuckey.web.filters.urlrewrite.RuleChain.handleRewrite(RuleChain.java:164) at org.tuckey.web.filters.urlrewrite.RuleChain.doRules(RuleChain.java:141) at org.tuckey.web.filters.urlrewrite.UrlRewriter.processRequest(UrlRewriter.java:90) at org.tuckey.web.filters.urlrewrite.UrlRewriteFilter.doFilter(UrlRewriteFilter.java:406) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166) at com.lyt.util.filter.UrlRedirectFilter.doFilter(UrlRedirectFilter.java:52) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166) at com.lyt.util.filter.CsrfFilter.doFilter(CsrfFilter.java:198) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166) at com.magtech.filter.UserGroupMapFilter.doFilter(UserGroupMapFilter.java:39) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166) at com.magtech.filter.XssFilter.doFilter(XssFilter.java:66) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166) at com.lyt.util.web.CharacterEncodingFilter.doFilter(CharacterEncodingFilter.java:64) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166) at com.lyt.util.filter.FrameTaoFilter.doFilter(FrameTaoFilter.java:29) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166) at com.lyt.util.filter.JournalIDFilter.doFilter(JournalIDFilter.java:80) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166) at com.lyt.util.filter.ReadRequestRefererFilter.doFilter(ReadRequestRefererFilter.java:32) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166) at com.lyt.util.filter.AuthenticationFilter.doFilter(AuthenticationFilter.java:107) at com.lyt.util.HttpFilter.doFilter(HttpFilter.java:46) at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:193) at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:166) at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:196) at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:97) at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:542) at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:135) at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:81) at org.apache.catalina.valves.RemoteIpValve.invoke(RemoteIpValve.java:769) at org.apache.catalina.valves.AbstractAccessLogValve.invoke(AbstractAccessLogValve.java:698) at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:78) at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:364) at org.apache.coyote.http11.Http11Processor.service(Http11Processor.java:624) at org.apache.coyote.AbstractProcessorLight.process(AbstractProcessorLight.java:65) at org.apache.coyote.AbstractProtocol$ConnectionHandler.process(AbstractProtocol.java:831) at org.apache.tomcat.util.net.NioEndpoint$SocketProcessor.doRun(NioEndpoint.java:1650) at org.apache.tomcat.util.net.SocketProcessorBase.run(SocketProcessorBase.java:49) at org.apache.tomcat.util.threads.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1191) at org.apache.tomcat.util.threads.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:659) at org.apache.tomcat.util.threads.TaskThread$WrappingRunnable.run(TaskThread.java:61) at java.lang.Thread.run(Thread.java:748)

From	Others	local

Times	10	93
Rate	10%	90%

Abstract

Just accepted	Online first	Issue

0	0	83

	From	local

	Times	83
	Rate	100%

[1]	WANG Jin, YE Kaixiao, TIAN Yan, LIU Ke, LIANG Liuling, LI Qingqian, HUANG Ning, WANG Xinting. Simultaneous determination of 22 antibiotics in environmental water samples by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry [J]. Chinese Journal of Chromatography, 2023, 41(3): 241-249.
[2]	YANG Piaopiao, HUANG Wei, LI Lixia, LIU Hong. Determination of new glucocorticoid called clobetasol acetate in cosmetics by ultra performance liquid chromatography-tandem mass spectrometry [J]. Chinese Journal of Chromatography, 2023, 41(3): 250-256.
[3]	LIU Zhaoyang, DONG Jun, LI Hongxia, YANG Ruiyue, SHAO Zhiyu, WANG Siming. Determination of phosphatidylethanol in whole-blood by liquid chromatography-tandem mass spectrometry based on intelligent scheduled time-zone acquisition technology and the application to population level survey [J]. Chinese Journal of Chromatography, 2023, 41(2): 131-141.
[4]	ZHAO Qianru, LIU Hua, MENG Yaping, LI Xiang, GAO Ruifang, LI Xiangsheng. Simultaneous determination of 83 glucocorticoids in cosmetics by ultra performance liquid chromatography-tandem mass spectrometry [J]. Chinese Journal of Chromatography, 2023, 41(12): 1084-1094.
[5]	LIU Leiqi, CHEN Jingze, FU Wusheng, TANG Cuiying. Determination of amanita peptide and tryptamine toxins in wild mushrooms by high performance liquid chromatography-tandem mass spectrometry [J]. Chinese Journal of Chromatography, 2023, 41(11): 976-985.
[6]	XU Dunming, WU Yifeng, WANG Yifan, CHEN Fangfang, ZHANG Shudi, LAI Guoyin. Simultaneous determination of 28 fragrance components in cosmetics by gas chromatography-tandem mass spectrometry [J]. Chinese Journal of Chromatography, 2023, 41(1): 76-86.
[7]	FENG Junjun, JIANG Haiyun, WANG Jing, JING Zhengyi, ZHANG Fan, TAN Tianyu, HE Feng, JIANG Lihua, LI Haiqin, CHANG Shimin, LI Tengfei. Simultaneous determination of 40 plant growth regulators, fungicides, insecticides, and antibiotics in bean sprouts by QuEChERS-high performance liquid chromatography-tandem mass spectrometry [J]. Chinese Journal of Chromatography, 2022, 40(9): 843-853.
[8]	ZHOU Zhiming, LI Jing, CHEN Zhanghao, WU Yingying, LU Tuliu, XIAO Shuxiong. Determination of 32 oxidative dyes by high performance liquid chromatography and confirmation by high performance liquid chromatography-tandem mass spectrometry [J]. Chinese Journal of Chromatography, 2022, 40(9): 797-809.
[9]	XIONG Chensihui, DING Tianming, LIU Jie, YI Ou, DING Xiaoping, XIE Yun. Rapid determination of 22 functional components in cosmetics using ultra-high performance liquid chromatography-linear ion trap/orbitrap high resolution mass spectrometry [J]. Chinese Journal of Chromatography, 2022, 40(9): 817-824.
[10]	LI Xiaohan, LU Yingying, DONG Yongzhen, JIANG Feng, FAN Zhiyong, PAN Hui, LIU Mingjun, CHEN Yiping. Separation and enrichment of trace aflatoxin B₁ in grains by magnetic nanomaterials based on SiO₂@Fe₃O₄ [J]. Chinese Journal of Chromatography, 2022, 40(8): 694-703.
[11]	LI Hongyan, YANG Huan, MA Chenyi, ZHANG Wanyue, XU Qingyu, CHEN Mingxue, MA Youning. Determination of three oryzanols in rice by mixed-mode solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry [J]. Chinese Journal of Chromatography, 2022, 40(8): 746-752.
[12]	CHEN Yan, HUANG Congling, JIANG Xunyuan, CHEN Zhiting, WANG Gang, WAN Kai, TANG Xuemei. Chiral separation of new chiral insecticide pyraquinil isomers and establishment of analytical methods in vegetables [J]. Chinese Journal of Chromatography, 2022, 40(7): 634-643.
[13]	XIAO Gengpeng, YUAN Lu, LUO Chunli, LUO Xiang, HUANG Yousheng. Simultaneous determination of seven dimethylcyclosiloxanes in cosmetics of different formulation systems by gel permeation chromatography purification-gas chromatography-tandem mass spectrometry [J]. Chinese Journal of Chromatography, 2022, 40(6): 576-583.
[14]	LI Yangjie, HUANG Jiaying, FANG Jihui, HUANG Zhiye. Fast screening and confirmation of 73 common prohibited compounds in cosmetics by ultra performance liquid chromatography-quadrupole-time-of-flight high resolution mass spectrometry [J]. Chinese Journal of Chromatography, 2022, 40(5): 433-442.
[15]	XU Dunming, ZENG Sanmei, LIU Xuncai, WANG Luxiao, FAN Qunyan, ZHANG Xiaojiang, FANG Enhua. Determination and level investigation of 45 hormones in edible bird's nest by solid phase extraction-high performance liquid chromatography-tandem mass spectrometry [J]. Chinese Journal of Chromatography, 2022, 40(5): 423-432.