Research progress on core-shell silica stationary phases for high performance liquid chromatography

doi:10.3724/SP.J.1123.2019.08014

Abstract

Abstract:

Fast and efficient separation by using high performance liquid chromatography (HPLC) is challenging for a wide range of samples. In recent years, core-shell silica microspheres have been widely investigated and used for highly efficient and fast separation under reasonably low pressure for small solutes, biopolymers, and complex samples. In this paper, the mechanism for fast separation and preparation methods of core-shell silica microspheres are introduced, along with their application for HPLC-based separation of small molecules, peptides, and biological macromolecules in HPLC. The developing trends of using core-shell microspheres in HPLC are also presented.

Key words: core-shell silica microspheres, high performance liquid chromatography (HPLC), fast separation and analysis, review

CLC Number:

O658

XIA Hongjun, LIU Jiawei, BAI Quan. Research progress on core-shell silica stationary phases for high performance liquid chromatography[J]. Chinese Journal of Chromatography, 2020, 38(4): 372-382.

Figures/Tables 3

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