Simultaneous determination of 24 phthalates in liquors using front adsorption technology and ultra performance liquid chromatography-tandem mass spectrometry

doi:10.3724/SP.J.1123.2016.03001

Abstract

Abstract:

A method for the simultaneous determination of 24 phthalates in liquors was developed by using front adsorption technology and ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The samples were diluted and cleaned-up by an HLB solid phase extraction cartridge. The front adsorption technology was used to suppress the interferences which came from plastic pipes in the UPLC-MS/MS. And then the targets were analyzed by UPLC-MS/MS under the positive ion mode using multiple reaction monitoring (MRM) mode. The calibration curves showed a good linearity in the range of 0.005-2.00 mg/L with r>0.99. The limits of detections (S/N=3) were 0.003-0.05 mg/kg. The average recoveries of the spiked samples were between 75.4% and 118.2% with the relative standard deviations (RSDs) of 4.0%-11.2%. The method could be used to simultaneously confirm the multi-residue of the 24 phthalates in liquors. And the method is simple, sensitive and stable.

Key words: front adsorbing technology, liquors, phthalates, ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)

CLC Number:

O658

WU Min, ZHENG Xianghua, ZHANG Zhigang, CHEN Yan, LIN Liyi, HUANG Zhiqiang. Simultaneous determination of 24 phthalates in liquors using front adsorption technology and ultra performance liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, 2016, 34(7): 673-680.

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