Rapid on-site screening of eight prohibited antibiotics in cosmetics using extraction nano-electrospray coupled with ion mobility spectrometry

doi:10.3724/SP.J.1123.2016.03019

Abstract

Abstract:

A rapid on-site method has been developed for the identification of eight prohibited antibiotics in cosmetics using extraction nano-electrospray coupled with ion mobility spectrometry. The experimental conditions for capillary pulling, extraction nano-electrospray, and ion mobility spectrometry were investigated and optimized. Under the optimum conditions, the limits of detection (LODs) for the eight prohibited antibiotics were 20 mg/kg. The instrumental analysis time for a single ion mobility spectrometry run was less than 20 ms, and the total period for sample analysis was less than 30 s. The suspicious positive samples were subjected to further verification by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The proposed method is rapid, efficient with greatly simplified work flows and can provide potential analytical possibility for outside-the-lab screening of cosmetics for the presence of illicit ingredients.

Key words: cosmetics, extraction nano-electrospray, ion mobility spectrometry (IMS), prohibited antibiotics, rapid on-site screening

CLC Number:

O658

MENG Xianshuang, MA Qiang, MA Longhua, CHEN Lihua, HAN Chao, BAI Hua, WU Qing. Rapid on-site screening of eight prohibited antibiotics in cosmetics using extraction nano-electrospray coupled with ion mobility spectrometry[J]. Chinese Journal of Chromatography, 2016, 34(6): 596-601.

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