Determination of dioxane residue in cosmetics by isotope dilution-headspace gas chromatography-mass spectrometry

doi:10.3724/SP.J.1123.2013.01012

Abstract

Abstract:

A comprehensive analytical method based on isotope dilution-headspace gas chromatography-mass spectrometry was developed for the determination of dioxane residue in the cosmetics. Cosmetic sample (2 g) was placed in a headspace vial. Then, 1 g sodium chloride, 1 mL d₈-dioxane solution (20 mg/L) and 9 mL water were added. The vial was sealed and heated at 70 ℃ for 40 min. The qualitative and quantitative analyses were carried out for the analyte in selected ion monitoring (SIM) mode after the chromatographic separation on an HP-5MS column (30 m×0.25 mm×0.25 μm). The limit of quantification (LOQ) for dioxane was 2.5 mg/kg. The mean recoveries were 90.5%-104.0% at the spiked levels of 2.5-50 mg/kg with the relative standard deviations in the range of 1.26%-3.98%. The method is accurate, simple, rapid, and applicable for the inspection of dioxane residue in cosmetics.

Key words: cosmetics, dioxane, headspace gas chromatography-mass spectrometry (HS-GC-MS), isotope dilution

CLC Number:

O658

LI Jingrui, MA Qiang, LI Wentao, WANG Chao, BAI Hua, MA Huijuan, CAI Tianpei, JIAO Yang, ZHANG Xiaoli. Determination of dioxane residue in cosmetics by isotope dilution-headspace gas chromatography-mass spectrometry[J]. Chinese Journal of Chromatography, 2013, 31(5): 481-484.

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